RBM19-CLK2 Fusion FISH Probe
The RBM19-CLK2 Fusion FISH Probe is used to confirm a fusion of the RBM19 and CLK2 genes. The fusion of the RBM19 and CLK2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RBM19-CLK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-RERE | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-REOR | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-REGO | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-REGR | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-REAQ | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-ORRE | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-OROR | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-ORGO | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-GORE | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-GOOR | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-GOGO | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-GOGR | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-GRRE | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-GROR | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-GRGO | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-GRGR | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-AQRE | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-AQOR | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-AQGO | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-AQGR | 20 (40 μL) | 200 μL |
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| RBM19-CLK2-20-AQAQ | 20 (40 μL) | 200 μL |
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CLK2 Gene Summary
This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Name: CDC Like Kinase 2
Chromosome: CHR1: 155232658 -155243281
Locus: 1q22
RBM19 Gene Summary
This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Apr 2009]
Gene Name: RNA Binding Motif Protein 19
Chromosome: CHR12: 114254542 -114404176
Locus: 12q24.13-q24.21
Gene Diseases
The RBM19 CLK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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