RBM45-DGUOK Fusion FISH Probe
The RBM45-DGUOK Fusion FISH Probe is used to confirm a fusion of the RBM45 and DGUOK genes. The fusion of the RBM45 and DGUOK genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RBM45-DGUOK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-RERE | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-REOR | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-REGO | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-REGR | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-REAQ | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-ORRE | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-OROR | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-ORGO | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-ORAQ | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-GORE | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-GOOR | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-GOGO | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-GOGR | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-GOAQ | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-GRRE | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-GROR | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-GRGO | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-GRGR | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-GRAQ | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-AQRE | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-AQOR | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-AQGO | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-AQGR | 20 (40 μL) | 200 μL |
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| RBM45-DGUOK-20-AQAQ | 20 (40 μL) | 200 μL |
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DGUOK Gene Summary
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Deoxyguanosine Kinase
Chromosome: CHR2: 74153952 -74186088
Locus: 2p13.1
RBM45 Gene Summary
This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]
Gene Name: RNA Binding Motif Protein 45
Chromosome: CHR2: 178977181 -178994382
Locus: 2q31.2
Gene Diseases
The RBM45 DGUOK Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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