RCAN1-RUNX1 Fusion FISH Probe
The RCAN1-RUNX1 Fusion FISH Probe is used to confirm a fusion of the RCAN1 and RUNX1 genes. The fusion of the RCAN1 and RUNX1 genes has been associated with Breast Invasive Carcinoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RCAN1-RUNX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-RERE | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-REOR | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-REGO | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-REGR | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-REAQ | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-ORRE | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-OROR | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-ORGO | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-GORE | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-GOOR | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-GOGO | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-GOGR | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-GRRE | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-GROR | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-GRGO | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-GRGR | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-AQRE | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-AQOR | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-AQGO | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-AQGR | 20 (40 μL) | 200 μL |
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| RCAN1-RUNX1-20-AQAQ | 20 (40 μL) | 200 μL |
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RUNX1 Gene Summary
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Runt Related Transcription Factor 1
Chromosome: CHR21: 36160097 -36421595
Locus: 21q22.12
RCAN1 Gene Summary
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: Regulator Of Calcineurin 1
Chromosome: CHR21: 35888783 -35987382
Locus: 21q22.12
Gene Diseases
The RCAN1 RUNX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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