RCBTB2-EPSTI1 Fusion FISH Probe
The RCBTB2-EPSTI1 Fusion FISH Probe is used to confirm a fusion of the RCBTB2 and EPSTI1 genes. The fusion of the RCBTB2 and EPSTI1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RCBTB2-EPSTI1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-RERE | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-REOR | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-REGO | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-REGR | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-REAQ | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-ORRE | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-OROR | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-ORGO | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-GORE | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-GOOR | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-GOGO | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-GOGR | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-GRRE | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-GROR | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-GRGO | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-GRGR | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-AQRE | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-AQOR | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-AQGO | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-AQGR | 20 (40 μL) | 200 μL |
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| RCBTB2-EPSTI1-20-AQAQ | 20 (40 μL) | 200 μL |
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RCBTB2 Gene Summary
This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: RCC1 And BTB Domain Containing Protein 2
Chromosome: CHR13: 49063098 -49107316
Locus: 13q14.2
EPSTI1 Gene Summary
The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE). [provided by RefSeq, Sep 2016]
Gene Name: Epithelial Stromal Interaction 1
Chromosome: CHR13: 43462121 -43566377
Locus: 13q14.11
Gene Diseases
The RCBTB2 EPSTI1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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