RELN-CHRM2 Fusion FISH Probe
The RELN-CHRM2 Fusion FISH Probe is used to confirm a fusion of the RELN and CHRM2 genes. The fusion of the RELN and CHRM2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RELN-CHRM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-RERE | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-REOR | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-REGO | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-REGR | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-REAQ | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-ORRE | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-OROR | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-ORGO | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-GORE | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-GOOR | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-GOGO | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-GOGR | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-GRRE | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-GROR | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-GRGO | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-GRGR | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-AQRE | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-AQOR | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-AQGO | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-AQGR | 20 (40 μL) | 200 μL |
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| RELN-CHRM2-20-AQAQ | 20 (40 μL) | 200 μL |
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CHRM2 Gene Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Cholinergic Receptor Muscarinic 2
Chromosome: CHR7: 136553398 -136701771
Locus: 7q33
RELN Gene Summary
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Reelin
Chromosome: CHR7: 103112230 -103629963
Locus: 7q22.1
Gene Diseases
The RELN CHRM2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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