RNF11-C8A Fusion FISH Probe
The RNF11-C8A Fusion FISH Probe is used to confirm a fusion of the RNF11 and C8A genes. The fusion of the RNF11 and C8A genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF11-C8A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-RERE | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-REOR | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-REGO | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-REGR | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-OROR | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-GORE | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-GROR | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF11-C8A-20-AQAQ | 20 (40 μL) | 200 μL |
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C8A Gene Summary
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
Gene Name: Complement C8 Alpha Chain
Chromosome: CHR1: 57320442 -57383894
Locus: 1p32.2
RNF11 Gene Summary
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]
Gene Name: Ring Finger Protein 11
Chromosome: CHR1: 51701944 -51739119
Locus: 1p32.3
Gene Diseases
The RNF11 C8A Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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