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RNF111-TCF12 Fusion FISH Probe

The RNF111-TCF12 Fusion FISH Probe is used to confirm a fusion of the RNF111 and TCF12 genes. The fusion of the RNF111 and TCF12 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
RNF111-TCF12-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
RNF111-TCF12-20-RERE 20 (40 μL) 200 μL
RNF111-TCF12-20-REOR 20 (40 μL) 200 μL
RNF111-TCF12-20-REGO 20 (40 μL) 200 μL
RNF111-TCF12-20-REGR 20 (40 μL) 200 μL
RNF111-TCF12-20-REAQ 20 (40 μL) 200 μL
RNF111-TCF12-20-ORRE 20 (40 μL) 200 μL
RNF111-TCF12-20-OROR 20 (40 μL) 200 μL
RNF111-TCF12-20-ORGO 20 (40 μL) 200 μL
RNF111-TCF12-20-ORAQ 20 (40 μL) 200 μL
RNF111-TCF12-20-GORE 20 (40 μL) 200 μL
RNF111-TCF12-20-GOOR 20 (40 μL) 200 μL
RNF111-TCF12-20-GOGO 20 (40 μL) 200 μL
RNF111-TCF12-20-GOGR 20 (40 μL) 200 μL
RNF111-TCF12-20-GOAQ 20 (40 μL) 200 μL
RNF111-TCF12-20-GRRE 20 (40 μL) 200 μL
RNF111-TCF12-20-GROR 20 (40 μL) 200 μL
RNF111-TCF12-20-GRGO 20 (40 μL) 200 μL
RNF111-TCF12-20-GRGR 20 (40 μL) 200 μL
RNF111-TCF12-20-GRAQ 20 (40 μL) 200 μL
RNF111-TCF12-20-AQRE 20 (40 μL) 200 μL
RNF111-TCF12-20-AQOR 20 (40 μL) 200 μL
RNF111-TCF12-20-AQGO 20 (40 μL) 200 μL
RNF111-TCF12-20-AQGR 20 (40 μL) 200 μL
RNF111-TCF12-20-AQAQ 20 (40 μL) 200 μL

TCF12 Gene Summary

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Name: Transcription Factor 12

Chromosome: CHR15: 57210832 -57580714

Locus: 15q21.3

RNF111 Gene Summary

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Gene Name: Ring Finger Protein 111

Chromosome: CHR15: 59279864 -59389253

Locus: 15q22.1-q22.2

Gene Diseases

The RNF111 TCF12 Fusion has been associated with the following diseases:

Disease Name
Liver Hepatocellular Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.