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RNF213-NVL Fusion FISH Probe

The RNF213-NVL Fusion FISH Probe is used to confirm a fusion of the RNF213 and NVL genes. The fusion of the RNF213 and NVL genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
RNF213-NVL-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
RNF213-NVL-20-RERE 20 (40 μL) 200 μL
RNF213-NVL-20-REOR 20 (40 μL) 200 μL
RNF213-NVL-20-REGO 20 (40 μL) 200 μL
RNF213-NVL-20-REGR 20 (40 μL) 200 μL
RNF213-NVL-20-REAQ 20 (40 μL) 200 μL
RNF213-NVL-20-ORRE 20 (40 μL) 200 μL
RNF213-NVL-20-OROR 20 (40 μL) 200 μL
RNF213-NVL-20-ORGO 20 (40 μL) 200 μL
RNF213-NVL-20-ORAQ 20 (40 μL) 200 μL
RNF213-NVL-20-GORE 20 (40 μL) 200 μL
RNF213-NVL-20-GOOR 20 (40 μL) 200 μL
RNF213-NVL-20-GOGO 20 (40 μL) 200 μL
RNF213-NVL-20-GOGR 20 (40 μL) 200 μL
RNF213-NVL-20-GOAQ 20 (40 μL) 200 μL
RNF213-NVL-20-GRRE 20 (40 μL) 200 μL
RNF213-NVL-20-GROR 20 (40 μL) 200 μL
RNF213-NVL-20-GRGO 20 (40 μL) 200 μL
RNF213-NVL-20-GRGR 20 (40 μL) 200 μL
RNF213-NVL-20-GRAQ 20 (40 μL) 200 μL
RNF213-NVL-20-AQRE 20 (40 μL) 200 μL
RNF213-NVL-20-AQOR 20 (40 μL) 200 μL
RNF213-NVL-20-AQGO 20 (40 μL) 200 μL
RNF213-NVL-20-AQGR 20 (40 μL) 200 μL
RNF213-NVL-20-AQAQ 20 (40 μL) 200 μL

NVL Gene Summary

This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]

Gene Name: Nuclear VCP-like

Chromosome: CHR1: 224415035 -224517891

Locus: 1q42.11

RNF213 Gene Summary

This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Gene Name: Ring Finger Protein 213

Chromosome: CHR17: 78234666 -78370086

Locus: 17q25.3

Gene Diseases

The RNF213 NVL Fusion has been associated with the following diseases:

Disease Name
Uterine Corpus Endometrial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.