RNF8-HIST1H2AC Fusion FISH Probe
The RNF8-HIST1H2AC Fusion FISH Probe is used to confirm a fusion of the RNF8 and HIST1H2AC genes. The fusion of the RNF8 and HIST1H2AC genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF8-HIST1H2AC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-RERE | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-REOR | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-REGO | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-REGR | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-OROR | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-GORE | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-GROR | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF8-HIST1H2AC-20-AQAQ | 20 (40 μL) | 200 μL |
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HIST1H2AC Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Gene Name: Histone Cluster 1 H2A Family Member C
Chromosome: CHR6: 26124372 -26124918
Locus: 6p22.2
RNF8 Gene Summary
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Name: Ring Finger Protein 8
Chromosome: CHR6: 37321747 -37362514
Locus: 6p21.2
Gene Diseases
The RNF8 HIST1H2AC Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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