ROBO1-HECW2 Fusion FISH Probe
The ROBO1-HECW2 Fusion FISH Probe is used to confirm a fusion of the ROBO1 and HECW2 genes. The fusion of the ROBO1 and HECW2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROBO1-HECW2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-RERE | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-REOR | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-REGO | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-REGR | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-REAQ | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-ORRE | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-OROR | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-ORGO | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-GORE | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-GOOR | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-GOGO | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-GOGR | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-GRRE | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-GROR | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-GRGO | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-GRGR | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-AQRE | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-AQOR | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-AQGO | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-AQGR | 20 (40 μL) | 200 μL |
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| ROBO1-HECW2-20-AQAQ | 20 (40 μL) | 200 μL |
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ROBO1 Gene Summary
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: Roundabout Guidance Receptor 1
Chromosome: CHR3: 78646387 -79817059
Locus: 3p12.3
HECW2 Gene Summary
This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Gene Name: HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2
Chromosome: CHR2: 197063976 -197457335
Locus: 2q32.3
Gene Diseases
The ROBO1 HECW2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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