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ROCK1-ABHD3 Fusion FISH Probe

The ROCK1-ABHD3 Fusion FISH Probe is used to confirm a fusion of the ROCK1 and ABHD3 genes. The fusion of the ROCK1 and ABHD3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ROCK1-ABHD3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ROCK1-ABHD3-20-RERE 20 (40 μL) 200 μL
ROCK1-ABHD3-20-REOR 20 (40 μL) 200 μL
ROCK1-ABHD3-20-REGO 20 (40 μL) 200 μL
ROCK1-ABHD3-20-REGR 20 (40 μL) 200 μL
ROCK1-ABHD3-20-REAQ 20 (40 μL) 200 μL
ROCK1-ABHD3-20-ORRE 20 (40 μL) 200 μL
ROCK1-ABHD3-20-OROR 20 (40 μL) 200 μL
ROCK1-ABHD3-20-ORGO 20 (40 μL) 200 μL
ROCK1-ABHD3-20-ORAQ 20 (40 μL) 200 μL
ROCK1-ABHD3-20-GORE 20 (40 μL) 200 μL
ROCK1-ABHD3-20-GOOR 20 (40 μL) 200 μL
ROCK1-ABHD3-20-GOGO 20 (40 μL) 200 μL
ROCK1-ABHD3-20-GOGR 20 (40 μL) 200 μL
ROCK1-ABHD3-20-GOAQ 20 (40 μL) 200 μL
ROCK1-ABHD3-20-GRRE 20 (40 μL) 200 μL
ROCK1-ABHD3-20-GROR 20 (40 μL) 200 μL
ROCK1-ABHD3-20-GRGO 20 (40 μL) 200 μL
ROCK1-ABHD3-20-GRGR 20 (40 μL) 200 μL
ROCK1-ABHD3-20-GRAQ 20 (40 μL) 200 μL
ROCK1-ABHD3-20-AQRE 20 (40 μL) 200 μL
ROCK1-ABHD3-20-AQOR 20 (40 μL) 200 μL
ROCK1-ABHD3-20-AQGO 20 (40 μL) 200 μL
ROCK1-ABHD3-20-AQGR 20 (40 μL) 200 μL
ROCK1-ABHD3-20-AQAQ 20 (40 μL) 200 μL

ROCK1 Gene Summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]

Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1

Chromosome: CHR18: 18529702 -18691812

Locus: 18q11.1

ABHD3 Gene Summary

This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]

Gene Name: Abhydrolase Domain Containing 3

Chromosome: CHR18: 19230857 -19284766

Locus: 18q11.2

Gene Diseases

The ROCK1 ABHD3 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.