ROCK1-LAMA3 Fusion FISH Probe
The ROCK1-LAMA3 Fusion FISH Probe is used to confirm a fusion of the ROCK1 and LAMA3 genes. The fusion of the ROCK1 and LAMA3 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROCK1-LAMA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-RERE | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-REOR | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-REGO | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-REGR | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-REAQ | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-ORRE | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-OROR | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-ORGO | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-GORE | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-GOOR | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-GOGO | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-GOGR | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-GRRE | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-GROR | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-GRGO | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-GRGR | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-AQRE | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-AQOR | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-AQGO | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-AQGR | 20 (40 μL) | 200 μL |
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| ROCK1-LAMA3-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMA3 Gene Summary
The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Laminin Subunit Alpha 3
Chromosome: CHR18: 21269561 -21535029
Locus: 18q11.2
ROCK1 Gene Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1
Chromosome: CHR18: 18529702 -18691812
Locus: 18q11.1
Gene Diseases
The ROCK1 LAMA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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