ROCK2-DTNB Fusion FISH Probe
The ROCK2-DTNB Fusion FISH Probe is used to confirm a fusion of the ROCK2 and DTNB genes. The fusion of the ROCK2 and DTNB genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROCK2-DTNB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-RERE | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-REOR | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-REGO | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-REGR | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-REAQ | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-ORRE | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-OROR | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-ORGO | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-GORE | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-GOOR | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-GOGO | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-GOGR | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-GRRE | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-GROR | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-GRGO | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-GRGR | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-AQRE | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-AQOR | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-AQGO | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-AQGR | 20 (40 μL) | 200 μL |
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| ROCK2-DTNB-20-AQAQ | 20 (40 μL) | 200 μL |
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DTNB Gene Summary
This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]
Gene Name: Dystrobrevin Beta
Chromosome: CHR2: 25600111 -25896503
Locus: 2p23.3
ROCK2 Gene Summary
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 2
Chromosome: CHR2: 11321777 -11484711
Locus: 2p25.1
Gene Diseases
The ROCK2 DTNB Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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