ROR1-IL12RB2 Fusion FISH Probe
The ROR1-IL12RB2 Fusion FISH Probe is used to confirm a fusion of the ROR1 and IL12RB2 genes. The fusion of the ROR1 and IL12RB2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROR1-IL12RB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-RERE | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-REOR | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-REGO | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-REGR | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-REAQ | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-ORRE | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-OROR | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-ORGO | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-GORE | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-GOOR | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-GOGO | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-GOGR | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-GRRE | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-GROR | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-GRGO | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-GRGR | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-AQRE | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-AQOR | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-AQGO | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-AQGR | 20 (40 μL) | 200 μL |
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| ROR1-IL12RB2-20-AQAQ | 20 (40 μL) | 200 μL |
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IL12RB2 Gene Summary
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: Interleukin 12 Receptor Subunit Beta 2
Chromosome: CHR1: 67773046 -67862583
Locus: 1p31.3
ROR1 Gene Summary
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Gene Name: Receptor Tyrosine Kinase Like Orphan Receptor 1
Chromosome: CHR1: 64239689 -64644707
Locus: 1p31.3
Gene Diseases
The ROR1 IL12RB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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