RPL18-COL1A1 Fusion FISH Probe
The RPL18-COL1A1 Fusion FISH Probe is used to confirm a fusion of the RPL18 and COL1A1 genes. The fusion of the RPL18 and COL1A1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPL18-COL1A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-RERE | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-REOR | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-REGO | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-REGR | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-REAQ | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-ORRE | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-OROR | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-ORGO | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-GORE | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-GOOR | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-GOGO | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-GOGR | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-GRRE | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-GROR | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-GRGO | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-GRGR | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-AQRE | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-AQOR | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-AQGO | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-AQGR | 20 (40 μL) | 200 μL |
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| RPL18-COL1A1-20-AQAQ | 20 (40 μL) | 200 μL |
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COL1A1 Gene Summary
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Gene Name: Collagen Type I Alpha 1 Chain
Chromosome: CHR17: 48261456 -48279000
Locus: 17q21.33
RPL18 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Ribosomal Protein L18
Chromosome: CHR19: 49118587 -49122433
Locus: 19q13.33
Gene Diseases
The RPL18 COL1A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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