RPL18-TAGLN Fusion FISH Probe
The RPL18-TAGLN Fusion FISH Probe is used to confirm a fusion of the RPL18 and TAGLN genes. The fusion of the RPL18 and TAGLN genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RPL18-TAGLN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-RERE | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-REOR | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-REGO | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-REGR | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-OROR | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-GORE | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-GROR | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| RPL18-TAGLN-20-AQAQ | 20 (40 μL) | 200 μL |
|
RPL18 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Ribosomal Protein L18
Chromosome: CHR19: 49118587 -49122433
Locus: 19q13.33
TAGLN Gene Summary
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
Gene Name: Transgelin
Chromosome: CHR11: 117070039 -117075508
Locus: 11q23.3
Gene Diseases
The RPL18 TAGLN Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|