RSPH3-NOTCH4 Fusion FISH Probe
The RSPH3-NOTCH4 Fusion FISH Probe is used to confirm a fusion of the RSPH3 and NOTCH4 genes. The fusion of the RSPH3 and NOTCH4 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RSPH3-NOTCH4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-RERE | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-REOR | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-REGO | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-REGR | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-REAQ | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-ORRE | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-OROR | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-ORGO | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-ORAQ | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-GORE | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-GOOR | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-GOGO | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-GOGR | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-GOAQ | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-GRRE | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-GROR | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-GRGO | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-GRGR | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-GRAQ | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-AQRE | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-AQOR | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-AQGO | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-AQGR | 20 (40 μL) | 200 μL |
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| RSPH3-NOTCH4-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH4 Gene Summary
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Notch 4
Chromosome: CHR6_mann_hap4: 3505440 -3534689
Locus: 6p21.32
RSPH3 Gene Summary
The protein encoded by this gene acts as a protein kinase A anchoring protein. Mutations in this gene cause primary ciliary dyskinesia; a disorder characterized by defects of the axoneme in motile cilia and sperm flagella. The homolog of this gene was first identified in the blue-green algae Chlamydomonas as encoding a radial spoke protein that formed a structural component of motile cilia and flagella. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
Gene Name: Radial Spoke Head 3 Homolog
Chromosome: CHR6: 159398265 -159421198
Locus: 6q25.3
Gene Diseases
The RSPH3 NOTCH4 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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