RTN3-HRASLS5 Fusion FISH Probe
The RTN3-HRASLS5 Fusion FISH Probe is used to confirm a fusion of the RTN3 and HRASLS5 genes. The fusion of the RTN3 and HRASLS5 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RTN3-HRASLS5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-RERE | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-REOR | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-REGO | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-REGR | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-REAQ | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-ORRE | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-OROR | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-ORGO | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-ORAQ | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-GORE | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-GOOR | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-GOGO | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-GOGR | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-GOAQ | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-GRRE | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-GROR | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-GRGO | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-GRGR | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-GRAQ | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-AQRE | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-AQOR | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-AQGO | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-AQGR | 20 (40 μL) | 200 μL |
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| RTN3-HRASLS5-20-AQAQ | 20 (40 μL) | 200 μL |
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RTN3 Gene Summary
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
Gene Name: Reticulon 3
Chromosome: CHR11: 63448921 -63527363
Locus: 11q13.1
HRASLS5 Gene Summary
The HRAS Like Suppressor Family Member 5 (HRASLS5) gene is located on chr11 :63228875-63258680 at 11q12.3.
Gene Name: HRAS Like Suppressor Family Member 5
Chromosome: CHR11: 63228875 -63258680
Locus: 11q12.3
Gene Diseases
The RTN3 HRASLS5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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