RUNX1T1-E2F5 Fusion FISH Probe
The RUNX1T1-E2F5 Fusion FISH Probe is used to confirm a fusion of the RUNX1T1 and E2F5 genes. The fusion of the RUNX1T1 and E2F5 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RUNX1T1-E2F5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-RERE | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-REOR | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-REGO | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-REGR | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-REAQ | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-ORRE | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-OROR | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-ORGO | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-ORAQ | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-GORE | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-GOOR | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-GOGO | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-GOGR | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-GOAQ | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-GRRE | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-GROR | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-GRGO | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-GRGR | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-GRAQ | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-AQRE | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-AQOR | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-AQGO | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-AQGR | 20 (40 μL) | 200 μL |
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| RUNX1T1-E2F5-20-AQAQ | 20 (40 μL) | 200 μL |
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RUNX1T1 Gene Summary
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Name: RUNX1 Translocation Partner 1
Chromosome: CHR8: 92967194 -93115454
Locus: 8q21.3
E2F5 Gene Summary
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: E2F Transcription Factor 5
Chromosome: CHR8: 86089618 -86126753
Locus: 8q21.2
Gene Diseases
The RUNX1T1 E2F5 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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