RYBP-FHIT Fusion FISH Probe
The RYBP-FHIT Fusion FISH Probe is used to confirm a fusion of the RYBP and FHIT genes. The fusion of the RYBP and FHIT genes has been associated with Thymoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RYBP-FHIT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-RERE | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-REOR | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-REGO | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-REGR | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-REAQ | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-ORRE | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-OROR | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-ORGO | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-ORAQ | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-GORE | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-GOOR | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-GOGO | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-GOGR | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-GOAQ | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-GRRE | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-GROR | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-GRGO | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-GRGR | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-GRAQ | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-AQRE | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-AQOR | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-AQGO | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-AQGR | 20 (40 μL) | 200 μL |
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| RYBP-FHIT-20-AQAQ | 20 (40 μL) | 200 μL |
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FHIT Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035 -61237133
Locus: 3p14.2
RYBP Gene Summary
The RING1 And YY1 Binding Protein (RYBP) gene is located on chr3 :72423743-72495774 at 3p13.
Gene Name: RING1 And YY1 Binding Protein
Chromosome: CHR3: 72423743 -72495774
Locus: 3p13
Gene Diseases
The RYBP FHIT Fusion has been associated with the following diseases:
| Disease Name |
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| Thymoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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