RYK-KALRN Fusion FISH Probe
The RYK-KALRN Fusion FISH Probe is used to confirm a fusion of the RYK and KALRN genes. The fusion of the RYK and KALRN genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RYK-KALRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-RERE | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-REOR | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-REGO | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-REGR | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-REAQ | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-ORRE | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-OROR | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-ORGO | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-GORE | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-GOOR | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-GOGO | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-GOGR | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-GRRE | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-GROR | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-GRGO | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-GRGR | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-AQRE | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-AQOR | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-AQGO | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-AQGR | 20 (40 μL) | 200 μL |
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| RYK-KALRN-20-AQAQ | 20 (40 μL) | 200 μL |
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RYK Gene Summary
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Gene Name: Receptor-like Tyrosine Kinase
Chromosome: CHR3: 133875977 -133969586
Locus: 3q22.2
KALRN Gene Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
Gene Name: Kalirin RhoGEF Kinase
Chromosome: CHR3: 123813557 -124440036
Locus: 3q21.1-q21.2
Gene Diseases
The RYK KALRN Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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