S100A6-BCL7A Fusion FISH Probe
The S100A6-BCL7A Fusion FISH Probe is used to confirm a fusion of the S100A6 and BCL7A genes. The fusion of the S100A6 and BCL7A genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| S100A6-BCL7A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-RERE | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-REOR | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-REGO | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-REGR | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-REAQ | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-ORRE | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-OROR | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-ORGO | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-ORAQ | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-GORE | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-GOOR | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-GOGO | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-GOGR | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-GOAQ | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-GRRE | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-GROR | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-GRGO | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-GRGR | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-GRAQ | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-AQRE | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-AQOR | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-AQGO | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-AQGR | 20 (40 μL) | 200 μL |
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| S100A6-BCL7A-20-AQAQ | 20 (40 μL) | 200 μL |
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BCL7A Gene Summary
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: BCL Tumor Suppressor 7A
Chromosome: CHR12: 122459860 -122499950
Locus: 12q24.31
S100A6 Gene Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]
Gene Name: S100 Calcium Binding Protein A6
Chromosome: CHR1: 153507075 -153508717
Locus: 1q21.3
Gene Diseases
The S100A6 BCL7A Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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