S100A8-TNNT1 Fusion FISH Probe
The S100A8-TNNT1 Fusion FISH Probe is used to confirm a fusion of the S100A8 and TNNT1 genes. The fusion of the S100A8 and TNNT1 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| S100A8-TNNT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-RERE | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-REOR | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-REGO | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-REGR | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-REAQ | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-ORRE | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-OROR | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-ORGO | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-GORE | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-GOOR | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-GOGO | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-GOGR | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-GRRE | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-GROR | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-GRGO | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-GRGR | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-AQRE | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-AQOR | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-AQGO | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-AQGR | 20 (40 μL) | 200 μL |
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| S100A8-TNNT1-20-AQAQ | 20 (40 μL) | 200 μL |
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S100A8 Gene Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Gene Name: S100 Calcium Binding Protein A8
Chromosome: CHR1: 153362507 -153363664
Locus: 1q21.3
TNNT1 Gene Summary
This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Troponin T1, Slow Skeletal Type
Chromosome: CHR19: 55644160 -55660606
Locus: 19q13.42
Gene Diseases
The S100A8 TNNT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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