S100B-TCTN1 Fusion FISH Probe
The S100B-TCTN1 Fusion FISH Probe is used to confirm a fusion of the S100B and TCTN1 genes. The fusion of the S100B and TCTN1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| S100B-TCTN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-RERE | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-REOR | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-REGO | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-REGR | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-REAQ | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-ORRE | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-OROR | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-ORGO | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-GORE | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-GOOR | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-GOGO | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-GOGR | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-GRRE | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-GROR | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-GRGO | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-GRGR | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-AQRE | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-AQOR | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-AQGO | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-AQGR | 20 (40 μL) | 200 μL |
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| S100B-TCTN1-20-AQAQ | 20 (40 μL) | 200 μL |
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S100B Gene Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
Gene Name: S100 Calcium Binding Protein B
Chromosome: CHR21: 48018530 -48025035
Locus: 21q22.3
TCTN1 Gene Summary
This gene encodes a member of a family of secreted and transmembrane proteins. The orthologous gene in mouse functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. This protein is a component of the tectonic-like complex, which forms a barrier between the ciliary axoneme and the basal body. A mutation in this gene was found in a family with Joubert syndrome-13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: Tectonic Family Member 1
Chromosome: CHR12: 111051831 -111086935
Locus: 12q24.11
Gene Diseases
The S100B TCTN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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