SACS-PHF3 Fusion FISH Probe
The SACS-PHF3 Fusion FISH Probe is used to confirm a fusion of the SACS and PHF3 genes. The fusion of the SACS and PHF3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SACS-PHF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-RERE | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-REOR | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-REGO | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-REGR | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-REAQ | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-ORRE | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-OROR | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-ORGO | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-GORE | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-GOOR | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-GOGO | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-GOGR | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-GRRE | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-GROR | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-GRGO | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-GRGR | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-AQRE | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-AQOR | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-AQGO | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-AQGR | 20 (40 μL) | 200 μL |
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| SACS-PHF3-20-AQAQ | 20 (40 μL) | 200 μL |
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PHF3 Gene Summary
This gene encodes a member of a PHD finger-containing gene family. This gene may function as a transcription factor and may be involved in glioblastomas development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: PHD Finger Protein 3
Chromosome: CHR6: 64356430 -64424405
Locus: 6q12
SACS Gene Summary
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al., PubMed: 19208651). A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: Sacsin Molecular Chaperone
Chromosome: CHR13: 23902964 -24007841
Locus: 13q12.12
Gene Diseases
The SACS PHF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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