SAE1-GRIN2D Fusion FISH Probe
The SAE1-GRIN2D Fusion FISH Probe is used to confirm a fusion of the SAE1 and GRIN2D genes. The fusion of the SAE1 and GRIN2D genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SAE1-GRIN2D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-RERE | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-REOR | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-REGO | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-REGR | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-REAQ | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-ORRE | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-OROR | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-ORGO | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-ORAQ | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-GORE | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-GOOR | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-GOGO | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-GOGR | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-GOAQ | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-GRRE | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-GROR | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-GRGO | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-GRGR | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-GRAQ | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-AQRE | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-AQOR | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-AQGO | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-AQGR | 20 (40 μL) | 200 μL |
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| SAE1-GRIN2D-20-AQAQ | 20 (40 μL) | 200 μL |
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GRIN2D Gene Summary
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]
Gene Name: Glutamate Ionotropic Receptor NMDA Type Subunit 2D
Chromosome: CHR19: 48898131 -48948188
Locus: 19q13.33
SAE1 Gene Summary
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Gene Name: SUMO1 Activating Enzyme Subunit 1
Chromosome: CHR19: 47634079 -47713893
Locus: 19q13.32
Gene Diseases
The SAE1 GRIN2D Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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