SAE1-HAS1 Fusion FISH Probe
The SAE1-HAS1 Fusion FISH Probe is used to confirm a fusion of the SAE1 and HAS1 genes. The fusion of the SAE1 and HAS1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SAE1-HAS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SAE1-HAS1-20-AQAQ | 20 (40 μL) | 200 μL |
|
HAS1 Gene Summary
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: Hyaluronan Synthase 1
Chromosome: CHR19: 52216364 -52227221
Locus: 19q13.41
SAE1 Gene Summary
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Gene Name: SUMO1 Activating Enzyme Subunit 1
Chromosome: CHR19: 47634079 -47713893
Locus: 19q13.32
Gene Diseases
The SAE1 HAS1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|