SART1-CNTN5 Fusion FISH Probe
The SART1-CNTN5 Fusion FISH Probe is used to confirm a fusion of the SART1 and CNTN5 genes. The fusion of the SART1 and CNTN5 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SART1-CNTN5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-RERE | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-REOR | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-REGO | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-REGR | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-REAQ | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-ORRE | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-OROR | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-ORGO | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-ORAQ | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-GORE | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-GOOR | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-GOGO | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-GOGR | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-GOAQ | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-GRRE | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-GROR | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-GRGO | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-GRGR | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-GRAQ | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-AQRE | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-AQOR | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-AQGO | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-AQGR | 20 (40 μL) | 200 μL |
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| SART1-CNTN5-20-AQAQ | 20 (40 μL) | 200 μL |
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SART1 Gene Summary
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
Gene Name: SART1, U4/U6.U5 Tri-snRNP-associated Protein 1
Chromosome: CHR11: 65729159 -65747607
Locus: 11q13.1
CNTN5 Gene Summary
The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Contactin 5
Chromosome: CHR11: 98891705 -100229616
Locus: 11q22.1
Gene Diseases
The SART1 CNTN5 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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