SEC31A-EIF4G3 Fusion FISH Probe
The SEC31A-EIF4G3 Fusion FISH Probe is used to confirm a fusion of the SEC31A and EIF4G3 genes. The fusion of the SEC31A and EIF4G3 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEC31A-EIF4G3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-RERE | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-REOR | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-REGO | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-REGR | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-REAQ | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-ORRE | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-OROR | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-ORGO | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-GORE | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-GOOR | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-GOGO | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-GOGR | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-GRRE | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-GROR | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-GRGO | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-GRGR | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-AQRE | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-AQOR | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-AQGO | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-AQGR | 20 (40 μL) | 200 μL |
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| SEC31A-EIF4G3-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF4G3 Gene Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 3
Chromosome: CHR1: 21132784 -21503381
Locus: 1p36.12
SEC31A Gene Summary
The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: SEC31 Homolog A, COPII Coat Complex Component
Chromosome: CHR4: 83739813 -83812419
Locus: 4q21.22
Gene Diseases
The SEC31A EIF4G3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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