SEC63-FIG4 Fusion FISH Probe
The SEC63-FIG4 Fusion FISH Probe is used to confirm a fusion of the SEC63 and FIG4 genes. The fusion of the SEC63 and FIG4 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEC63-FIG4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-RERE | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-REOR | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-REGO | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-REGR | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-REAQ | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-ORRE | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-OROR | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-ORGO | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-GORE | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-GOOR | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-GOGO | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-GOGR | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-GRRE | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-GROR | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-GRGO | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-GRGR | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-AQRE | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-AQOR | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-AQGO | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-AQGR | 20 (40 μL) | 200 μL |
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| SEC63-FIG4-20-AQAQ | 20 (40 μL) | 200 μL |
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FIG4 Gene Summary
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]
Gene Name: FIG4 Phosphoinositide 5-phosphatase
Chromosome: CHR6: 110012423 -110146634
Locus: 6q21
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The SEC63 FIG4 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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