SEMA3C-AUTS2 Fusion FISH Probe
The SEMA3C-AUTS2 Fusion FISH Probe is used to confirm a fusion of the SEMA3C and AUTS2 genes. The fusion of the SEMA3C and AUTS2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SEMA3C-AUTS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SEMA3C-AUTS2-20-AQAQ | 20 (40 μL) | 200 μL |
|
SEMA3C Gene Summary
This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
Gene Name: Semaphorin 3C
Chromosome: CHR7: 80371853 -80548667
Locus: 7q21.11
AUTS2 Gene Summary
This gene has been implicated in neurodevelopment and as a candidate gene for numerous neurological disorders, including autism spectrum disorders, intellectual disability, and developmental delay. Mutations in this gene have also been associated with non-neurological disorders, such as acute lymphoblastic leukemia, aging of the skin, early-onset androgenetic alopecia, and certain cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2014]
Gene Name: AUTS2, Activator Of Transcription And Developmental Regulator
Chromosome: CHR7: 69063905 -70257885
Locus: 7q11.22
Gene Diseases
The SEMA3C AUTS2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|