SEMA3C-PPP1R12C Fusion FISH Probe
The SEMA3C-PPP1R12C Fusion FISH Probe is used to confirm a fusion of the SEMA3C and PPP1R12C genes. The fusion of the SEMA3C and PPP1R12C genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEMA3C-PPP1R12C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-RERE | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-REOR | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-REGO | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-REGR | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-REAQ | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-ORRE | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-OROR | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-ORGO | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-GORE | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-GOOR | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-GOGO | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-GOGR | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-GRRE | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-GROR | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-GRGO | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-GRGR | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-AQRE | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-AQOR | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-AQGO | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-AQGR | 20 (40 μL) | 200 μL |
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| SEMA3C-PPP1R12C-20-AQAQ | 20 (40 μL) | 200 μL |
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SEMA3C Gene Summary
This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
Gene Name: Semaphorin 3C
Chromosome: CHR7: 80371853 -80548667
Locus: 7q21.11
PPP1R12C Gene Summary
The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 12C
Chromosome: CHR19: 55602280 -55628927
Locus: 19q13.42
Gene Diseases
The SEMA3C PPP1R12C Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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