SEMA3F-RNF123 Fusion FISH Probe
The SEMA3F-RNF123 Fusion FISH Probe is used to confirm a fusion of the SEMA3F and RNF123 genes. The fusion of the SEMA3F and RNF123 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEMA3F-RNF123-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-RERE | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-REOR | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-REGO | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-REGR | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-REAQ | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-ORRE | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-OROR | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-ORGO | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-GORE | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-GOOR | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-GOGO | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-GOGR | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-GRRE | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-GROR | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-GRGO | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-GRGR | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-AQRE | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-AQOR | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-AQGO | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-AQGR | 20 (40 μL) | 200 μL |
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| SEMA3F-RNF123-20-AQAQ | 20 (40 μL) | 200 μL |
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SEMA3F Gene Summary
This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Gene Name: Semaphorin 3F
Chromosome: CHR3: 50192847 -50226508
Locus: 3p21.31
RNF123 Gene Summary
The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: Ring Finger Protein 123
Chromosome: CHR3: 49726989 -49758962
Locus: 3p21.31
Gene Diseases
The SEMA3F RNF123 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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