SEMA6D-EXD1 Fusion FISH Probe
The SEMA6D-EXD1 Fusion FISH Probe is used to confirm a fusion of the SEMA6D and EXD1 genes. The fusion of the SEMA6D and EXD1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SEMA6D-EXD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-RERE | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-REOR | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-REGO | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-REGR | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-REAQ | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-ORRE | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-OROR | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-ORGO | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-GORE | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-GOOR | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-GOGO | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-GOGR | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-GRRE | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-GROR | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-GRGO | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-GRGR | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-AQRE | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-AQOR | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-AQGO | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-AQGR | 20 (40 μL) | 200 μL |
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| SEMA6D-EXD1-20-AQAQ | 20 (40 μL) | 200 μL |
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SEMA6D Gene Summary
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
Gene Name: Semaphorin 6D
Chromosome: CHR15: 47476402 -48066420
Locus: 15q21.1
EXD1 Gene Summary
The Exonuclease 3'-5' Domain Containing 1 (EXD1) gene is located on chr15 :41474930-41522895 at 15q15.1.
Gene Name: Exonuclease 3'-5' Domain Containing 1
Chromosome: CHR15: 41474930 -41522895
Locus: 15q15.1
Gene Diseases
The SEMA6D EXD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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