SENP5-KCNMB3 Fusion FISH Probe
The SENP5-KCNMB3 Fusion FISH Probe is used to confirm a fusion of the SENP5 and KCNMB3 genes. The fusion of the SENP5 and KCNMB3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SENP5-KCNMB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-RERE | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-REOR | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-REGO | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-REGR | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-REAQ | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-ORRE | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-OROR | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-ORGO | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-GORE | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-GOOR | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-GOGO | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-GOGR | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-GRRE | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-GROR | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-GRGO | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-GRGR | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-AQRE | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-AQOR | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-AQGO | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-AQGR | 20 (40 μL) | 200 μL |
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| SENP5-KCNMB3-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNMB3 Gene Summary
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]
Gene Name: Potassium Calcium-activated Channel Subfamily M Regulatory Beta Subunit 3
Chromosome: CHR3: 178957536 -178984838
Locus: 3q26.32
SENP5 Gene Summary
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Gene Name: SUMO1/sentrin Specific Peptidase 5
Chromosome: CHR3: 196594726 -196661584
Locus: 3q29
Gene Diseases
The SENP5 KCNMB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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