SENP5-PIGZ Fusion FISH Probe
The SENP5-PIGZ Fusion FISH Probe is used to confirm a fusion of the SENP5 and PIGZ genes. The fusion of the SENP5 and PIGZ genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SENP5-PIGZ-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-RERE | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-REOR | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-REGO | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-REGR | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-REAQ | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-ORRE | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-OROR | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-ORGO | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-ORAQ | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-GORE | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-GOOR | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-GOGO | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-GOGR | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-GOAQ | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-GRRE | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-GROR | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-GRGO | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-GRGR | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-GRAQ | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-AQRE | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-AQOR | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-AQGO | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-AQGR | 20 (40 μL) | 200 μL |
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| SENP5-PIGZ-20-AQAQ | 20 (40 μL) | 200 μL |
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PIGZ Gene Summary
The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]
Gene Name: Phosphatidylinositol Glycan Anchor Biosynthesis Class Z
Chromosome: CHR3: 196673213 -196695704
Locus: 3q29
SENP5 Gene Summary
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Gene Name: SUMO1/sentrin Specific Peptidase 5
Chromosome: CHR3: 196594726 -196661584
Locus: 3q29
Gene Diseases
The SENP5 PIGZ Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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