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SENP6-SLC35A1 Fusion FISH Probe

The SENP6-SLC35A1 Fusion FISH Probe is used to confirm a fusion of the SENP6 and SLC35A1 genes. The fusion of the SENP6 and SLC35A1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
SENP6-SLC35A1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SENP6-SLC35A1-20-RERE 20 (40 μL) 200 μL
SENP6-SLC35A1-20-REOR 20 (40 μL) 200 μL
SENP6-SLC35A1-20-REGO 20 (40 μL) 200 μL
SENP6-SLC35A1-20-REGR 20 (40 μL) 200 μL
SENP6-SLC35A1-20-REAQ 20 (40 μL) 200 μL
SENP6-SLC35A1-20-ORRE 20 (40 μL) 200 μL
SENP6-SLC35A1-20-OROR 20 (40 μL) 200 μL
SENP6-SLC35A1-20-ORGO 20 (40 μL) 200 μL
SENP6-SLC35A1-20-ORAQ 20 (40 μL) 200 μL
SENP6-SLC35A1-20-GORE 20 (40 μL) 200 μL
SENP6-SLC35A1-20-GOOR 20 (40 μL) 200 μL
SENP6-SLC35A1-20-GOGO 20 (40 μL) 200 μL
SENP6-SLC35A1-20-GOGR 20 (40 μL) 200 μL
SENP6-SLC35A1-20-GOAQ 20 (40 μL) 200 μL
SENP6-SLC35A1-20-GRRE 20 (40 μL) 200 μL
SENP6-SLC35A1-20-GROR 20 (40 μL) 200 μL
SENP6-SLC35A1-20-GRGO 20 (40 μL) 200 μL
SENP6-SLC35A1-20-GRGR 20 (40 μL) 200 μL
SENP6-SLC35A1-20-GRAQ 20 (40 μL) 200 μL
SENP6-SLC35A1-20-AQRE 20 (40 μL) 200 μL
SENP6-SLC35A1-20-AQOR 20 (40 μL) 200 μL
SENP6-SLC35A1-20-AQGO 20 (40 μL) 200 μL
SENP6-SLC35A1-20-AQGR 20 (40 μL) 200 μL
SENP6-SLC35A1-20-AQAQ 20 (40 μL) 200 μL

SLC35A1 Gene Summary

The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

Gene Name: Solute Carrier Family 35 Member A1

Chromosome: CHR6: 88182642 -88222057

Locus: 6q15

SENP6 Gene Summary

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

Gene Name: SUMO1/sentrin Specific Peptidase 6

Chromosome: CHR6: 76311621 -76427994

Locus: 6q14.1

Gene Diseases

The SENP6 SLC35A1 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.