SENP7-RFC4 Fusion FISH Probe
The SENP7-RFC4 Fusion FISH Probe is used to confirm a fusion of the SENP7 and RFC4 genes. The fusion of the SENP7 and RFC4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SENP7-RFC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-RERE | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-REOR | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-REGO | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-REGR | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-REAQ | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-ORRE | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-OROR | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-ORGO | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-GORE | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-GOOR | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-GOGO | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-GOGR | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-GRRE | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-GROR | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-GRGO | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-GRGR | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-AQRE | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-AQOR | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-AQGO | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-AQGR | 20 (40 μL) | 200 μL |
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| SENP7-RFC4-20-AQAQ | 20 (40 μL) | 200 μL |
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RFC4 Gene Summary
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Replication Factor C Subunit 4
Chromosome: CHR3: 186507681 -186524484
Locus: 3q27.3
SENP7 Gene Summary
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Gene Name: SUMO1/sentrin Specific Peptidase 7
Chromosome: CHR3: 101043117 -101232085
Locus: 3q12.3
Gene Diseases
The SENP7 RFC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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