SERPINA1-CD46 Fusion FISH Probe
The SERPINA1-CD46 Fusion FISH Probe is used to confirm a fusion of the SERPINA1 and CD46 genes. The fusion of the SERPINA1 and CD46 genes has been associated with Liver Hepatocellular Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SERPINA1-CD46-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-RERE | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-REOR | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-REGO | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-REGR | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-REAQ | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-ORRE | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-OROR | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-ORGO | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-ORAQ | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-GORE | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-GOOR | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-GOGO | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-GOGR | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-GOAQ | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-GRRE | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-GROR | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-GRGO | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-GRGR | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-GRAQ | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-AQRE | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-AQOR | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-AQGO | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-AQGR | 20 (40 μL) | 200 μL |
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| SERPINA1-CD46-20-AQAQ | 20 (40 μL) | 200 μL |
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CD46 Gene Summary
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Gene Name: CD46 Molecule
Chromosome: CHR1: 207925382 -207968861
Locus: 1q32.2
SERPINA1 Gene Summary
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Serpin Family A Member 1
Chromosome: CHR14: 94843083 -94857029
Locus: 14q32.13
Gene Diseases
The SERPINA1 CD46 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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