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SESN1-METTL1 Fusion FISH Probe

The SESN1-METTL1 Fusion FISH Probe is used to confirm a fusion of the SESN1 and METTL1 genes. The fusion of the SESN1 and METTL1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
SESN1-METTL1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SESN1-METTL1-20-RERE 20 (40 μL) 200 μL
SESN1-METTL1-20-REOR 20 (40 μL) 200 μL
SESN1-METTL1-20-REGO 20 (40 μL) 200 μL
SESN1-METTL1-20-REGR 20 (40 μL) 200 μL
SESN1-METTL1-20-REAQ 20 (40 μL) 200 μL
SESN1-METTL1-20-ORRE 20 (40 μL) 200 μL
SESN1-METTL1-20-OROR 20 (40 μL) 200 μL
SESN1-METTL1-20-ORGO 20 (40 μL) 200 μL
SESN1-METTL1-20-ORAQ 20 (40 μL) 200 μL
SESN1-METTL1-20-GORE 20 (40 μL) 200 μL
SESN1-METTL1-20-GOOR 20 (40 μL) 200 μL
SESN1-METTL1-20-GOGO 20 (40 μL) 200 μL
SESN1-METTL1-20-GOGR 20 (40 μL) 200 μL
SESN1-METTL1-20-GOAQ 20 (40 μL) 200 μL
SESN1-METTL1-20-GRRE 20 (40 μL) 200 μL
SESN1-METTL1-20-GROR 20 (40 μL) 200 μL
SESN1-METTL1-20-GRGO 20 (40 μL) 200 μL
SESN1-METTL1-20-GRGR 20 (40 μL) 200 μL
SESN1-METTL1-20-GRAQ 20 (40 μL) 200 μL
SESN1-METTL1-20-AQRE 20 (40 μL) 200 μL
SESN1-METTL1-20-AQOR 20 (40 μL) 200 μL
SESN1-METTL1-20-AQGO 20 (40 μL) 200 μL
SESN1-METTL1-20-AQGR 20 (40 μL) 200 μL
SESN1-METTL1-20-AQAQ 20 (40 μL) 200 μL

METTL1 Gene Summary

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]

Gene Name: Methyltransferase Like 1

Chromosome: CHR12: 58162350 -58165914

Locus: 12q14.1

SESN1 Gene Summary

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Gene Name: Sestrin 1

Chromosome: CHR6: 109307639 -109415708

Locus: 6q21

Gene Diseases

The SESN1 METTL1 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.