SETD5-RAD18 Fusion FISH Probe
The SETD5-RAD18 Fusion FISH Probe is used to confirm a fusion of the SETD5 and RAD18 genes. The fusion of the SETD5 and RAD18 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SETD5-RAD18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-RERE | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-REOR | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-REGO | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-REGR | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-REAQ | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-ORRE | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-OROR | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-ORGO | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-ORAQ | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-GORE | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-GOOR | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-GOGO | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-GOGR | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-GOAQ | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-GRRE | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-GROR | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-GRGO | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-GRGR | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-GRAQ | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-AQRE | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-AQOR | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-AQGO | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-AQGR | 20 (40 μL) | 200 μL |
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| SETD5-RAD18-20-AQAQ | 20 (40 μL) | 200 μL |
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SETD5 Gene Summary
This function of this gene has yet to be determined but based on sequence similarity to other SET domain proteins it may function as a histone methyltransferase. Mutations in this gene have been associated with an autosomal dominant form of intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Gene Name: SET Domain Containing 5
Chromosome: CHR3: 9439402 -9519838
Locus: 3p25.3
RAD18 Gene Summary
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Gene Name: RAD18, E3 Ubiquitin Protein Ligase
Chromosome: CHR3: 8918879 -9005159
Locus: 3p25.3
Gene Diseases
The SETD5 RAD18 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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