SETDB2-AATF Fusion FISH Probe
The SETDB2-AATF Fusion FISH Probe is used to confirm a fusion of the SETDB2 and AATF genes. The fusion of the SETDB2 and AATF genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SETDB2-AATF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-RERE | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-REOR | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-REGO | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-REGR | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-REAQ | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-ORRE | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-OROR | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-ORGO | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-ORAQ | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-GORE | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-GOOR | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-GOGO | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-GOGR | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-GOAQ | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-GRRE | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-GROR | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-GRGO | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-GRGR | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-GRAQ | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-AQRE | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-AQOR | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-AQGO | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-AQGR | 20 (40 μL) | 200 μL |
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| SETDB2-AATF-20-AQAQ | 20 (40 μL) | 200 μL |
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AATF Gene Summary
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
Gene Name: Apoptosis Antagonizing Transcription Factor
Chromosome: CHR17: 35306174 -35414171
Locus: 17q12
SETDB2 Gene Summary
This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Name: SET Domain Bifurcated 2
Chromosome: CHR13: 50018428 -50069139
Locus: 13q14.2
Gene Diseases
The SETDB2 AATF Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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