SF3B1-HSPD1 Fusion FISH Probe
The SF3B1-HSPD1 Fusion FISH Probe is used to confirm a fusion of the SF3B1 and HSPD1 genes. The fusion of the SF3B1 and HSPD1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SF3B1-HSPD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-RERE | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-REOR | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-REGO | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-REGR | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-REAQ | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-ORRE | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-OROR | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-ORGO | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-GORE | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-GOOR | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-GOGO | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-GOGR | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-GRRE | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-GROR | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-GRGO | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-GRGR | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-AQRE | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-AQOR | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-AQGO | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-AQGR | 20 (40 μL) | 200 μL |
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| SF3B1-HSPD1-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPD1 Gene Summary
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]
Gene Name: Heat Shock Protein Family D (Hsp60) Member 1
Chromosome: CHR2: 198351307 -198364998
Locus: 2q33.1
SF3B1 Gene Summary
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Splicing Factor 3b Subunit 1
Chromosome: CHR2: 198256697 -198299771
Locus: 2q33.1
Gene Diseases
The SF3B1 HSPD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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