SF3B3-CDH15 Fusion FISH Probe
The SF3B3-CDH15 Fusion FISH Probe is used to confirm a fusion of the SF3B3 and CDH15 genes. The fusion of the SF3B3 and CDH15 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SF3B3-CDH15-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-RERE | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-REOR | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-REGO | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-REGR | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-REAQ | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-ORRE | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-OROR | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-ORGO | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-ORAQ | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-GORE | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-GOOR | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-GOGO | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-GOGR | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-GOAQ | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-GRRE | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-GROR | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-GRGO | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-GRGR | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-GRAQ | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-AQRE | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-AQOR | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-AQGO | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-AQGR | 20 (40 μL) | 200 μL |
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| SF3B3-CDH15-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH15 Gene Summary
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]
Gene Name: Cadherin 15
Chromosome: CHR16: 89238162 -89261900
Locus: 16q24.3
SF3B3 Gene Summary
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
Gene Name: Splicing Factor 3b Subunit 3
Chromosome: CHR16: 70557690 -70611571
Locus: 16q22.1
Gene Diseases
The SF3B3 CDH15 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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