SF3B3-DDX19B Fusion FISH Probe
The SF3B3-DDX19B Fusion FISH Probe is used to confirm a fusion of the SF3B3 and DDX19B genes. The fusion of the SF3B3 and DDX19B genes has been associated with Glioblastoma Multiforme, Bladder Urothelial Carcinoma, and Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SF3B3-DDX19B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-RERE | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-REOR | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-REGO | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-REGR | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-REAQ | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-ORRE | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-OROR | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-ORGO | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-ORAQ | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-GORE | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-GOOR | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-GOGO | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-GOGR | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-GOAQ | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-GRRE | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-GROR | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-GRGO | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-GRGR | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-GRAQ | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-AQRE | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-AQOR | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-AQGO | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-AQGR | 20 (40 μL) | 200 μL |
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| SF3B3-DDX19B-20-AQAQ | 20 (40 μL) | 200 μL |
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DDX19B Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: DEAD-box Helicase 19B
Chromosome: CHR16: 70333071 -70367731
Locus: 16q22.1
SF3B3 Gene Summary
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
Gene Name: Splicing Factor 3b Subunit 3
Chromosome: CHR16: 70557690 -70611571
Locus: 16q22.1
Gene Diseases
The SF3B3 DDX19B Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
| Bladder Urothelial Carcinoma |
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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