SFTPC-SUPT16H Fusion FISH Probe
The SFTPC-SUPT16H Fusion FISH Probe is used to confirm a fusion of the SFTPC and SUPT16H genes. The fusion of the SFTPC and SUPT16H genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SFTPC-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| SFTPC-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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SFTPC Gene Summary
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]
Gene Name: Surfactant Protein C
Chromosome: CHR8: 22019183 -22021991
Locus: 8p21.3
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The SFTPC SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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