SGCB-SPATA18 Fusion FISH Probe
The SGCB-SPATA18 Fusion FISH Probe is used to confirm a fusion of the SGCB and SPATA18 genes. The fusion of the SGCB and SPATA18 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SGCB-SPATA18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-RERE | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-REOR | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-REGO | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-REGR | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-REAQ | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-ORRE | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-OROR | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-ORGO | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-ORAQ | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-GORE | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-GOOR | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-GOGO | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-GOGR | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-GOAQ | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-GRRE | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-GROR | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-GRGO | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-GRGR | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-GRAQ | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-AQRE | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-AQOR | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-AQGO | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-AQGR | 20 (40 μL) | 200 μL |
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| SGCB-SPATA18-20-AQAQ | 20 (40 μL) | 200 μL |
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SGCB Gene Summary
This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]
Gene Name: Sarcoglycan Beta
Chromosome: CHR4: 52886860 -52904485
Locus: 4q12
SPATA18 Gene Summary
This gene encodes a p53-inducible protein that is able to induce lysosome-like organelles within mitochondria that eliminate oxidized mitochondrial proteins, thereby contributing to mitochondrial quality control. Dysregulation of mitochondrial quality control is associated with cancer and degenerative diseases. The encoded protein mediates accumulation of the lysosome-like mitochondrial organelles through interaction with B cell lymphoma 2 interacting protein 3 and B cell lymphoma 2 interacting protein 3 like at the outer mitochondrial membrane, which allows translocation of lysosomal proteins to the mitochondrial matrix from the cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Gene Name: Spermatogenesis Associated 18
Chromosome: CHR4: 52917592 -52963458
Locus: 4q12
Gene Diseases
The SGCB SPATA18 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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