SH3D19-INPP4B Fusion FISH Probe
The SH3D19-INPP4B Fusion FISH Probe is used to confirm a fusion of the SH3D19 and INPP4B genes. The fusion of the SH3D19 and INPP4B genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SH3D19-INPP4B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-RERE | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-REOR | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-REGO | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-REGR | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-REAQ | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-ORRE | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-OROR | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-ORGO | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-ORAQ | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-GORE | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-GOOR | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-GOGO | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-GOGR | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-GOAQ | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-GRRE | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-GROR | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-GRGO | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-GRGR | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-GRAQ | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-AQRE | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-AQOR | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-AQGO | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-AQGR | 20 (40 μL) | 200 μL |
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| SH3D19-INPP4B-20-AQAQ | 20 (40 μL) | 200 μL |
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INPP4B Gene Summary
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Gene Name: Inositol Polyphosphate-4-phosphatase Type II B
Chromosome: CHR4: 142949181 -143767604
Locus: 4q31.21
SH3D19 Gene Summary
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: SH3 Domain Containing 19
Chromosome: CHR4: 152041432 -152149182
Locus: 4q31.3
Gene Diseases
The SH3D19 INPP4B Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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