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SHANK2-SYT7 Fusion FISH Probe

The SHANK2-SYT7 Fusion FISH Probe is used to confirm a fusion of the SHANK2 and SYT7 genes. The fusion of the SHANK2 and SYT7 genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
SHANK2-SYT7-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SHANK2-SYT7-20-RERE 20 (40 μL) 200 μL
SHANK2-SYT7-20-REOR 20 (40 μL) 200 μL
SHANK2-SYT7-20-REGO 20 (40 μL) 200 μL
SHANK2-SYT7-20-REGR 20 (40 μL) 200 μL
SHANK2-SYT7-20-REAQ 20 (40 μL) 200 μL
SHANK2-SYT7-20-ORRE 20 (40 μL) 200 μL
SHANK2-SYT7-20-OROR 20 (40 μL) 200 μL
SHANK2-SYT7-20-ORGO 20 (40 μL) 200 μL
SHANK2-SYT7-20-ORAQ 20 (40 μL) 200 μL
SHANK2-SYT7-20-GORE 20 (40 μL) 200 μL
SHANK2-SYT7-20-GOOR 20 (40 μL) 200 μL
SHANK2-SYT7-20-GOGO 20 (40 μL) 200 μL
SHANK2-SYT7-20-GOGR 20 (40 μL) 200 μL
SHANK2-SYT7-20-GOAQ 20 (40 μL) 200 μL
SHANK2-SYT7-20-GRRE 20 (40 μL) 200 μL
SHANK2-SYT7-20-GROR 20 (40 μL) 200 μL
SHANK2-SYT7-20-GRGO 20 (40 μL) 200 μL
SHANK2-SYT7-20-GRGR 20 (40 μL) 200 μL
SHANK2-SYT7-20-GRAQ 20 (40 μL) 200 μL
SHANK2-SYT7-20-AQRE 20 (40 μL) 200 μL
SHANK2-SYT7-20-AQOR 20 (40 μL) 200 μL
SHANK2-SYT7-20-AQGO 20 (40 μL) 200 μL
SHANK2-SYT7-20-AQGR 20 (40 μL) 200 μL
SHANK2-SYT7-20-AQAQ 20 (40 μL) 200 μL

SYT7 Gene Summary

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Gene Name: Synaptotagmin 7

Chromosome: CHR11: 61282784 -61348298

Locus: 11q12.2

SHANK2 Gene Summary

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Name: SH3 And Multiple Ankyrin Repeat Domains 2

Chromosome: CHR11: 70313960 -70935808

Locus: 11q13.3-q13.4

Gene Diseases

The SHANK2 SYT7 Fusion has been associated with the following diseases:

Disease Name
Rectum Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.