SHB-PAX5 Fusion FISH Probe
The SHB-PAX5 Fusion FISH Probe is used to confirm a fusion of the SHB and PAX5 genes. The fusion of the SHB and PAX5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHB-PAX5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-RERE | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-REOR | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-REGO | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-REGR | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-REAQ | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-ORRE | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-OROR | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-ORGO | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-GORE | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-GOOR | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-GOGO | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-GOGR | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-GRRE | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-GROR | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-GRGO | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-GRGR | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-AQRE | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-AQOR | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-AQGO | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-AQGR | 20 (40 μL) | 200 μL |
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| SHB-PAX5-20-AQAQ | 20 (40 μL) | 200 μL |
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PAX5 Gene Summary
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Name: Paired Box 5
Chromosome: CHR9: 36838530 -37034476
Locus: 9p13.2
SHB Gene Summary
The SH2 Domain Containing Adaptor Protein B (SHB) gene is located on chr9 :37915894-38069210 at 9p13.1.
Gene Name: SH2 Domain Containing Adaptor Protein B
Chromosome: CHR9: 37915894 -38069210
Locus: 9p13.1
Gene Diseases
The SHB PAX5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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